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Retracing Prenatal Testing Algorithms

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Abstract A good understanding of the statistical procedure used to calculate trisomy 21 (Down syndrome) risk in combined first trimester screening is a precondition for taking an informed decision on how to proceed with the screening results. For this purpose we implement the Fetal Medicine Foundation (FMF) Germany procedure described in Merz et al. (2016). To allow soon-to-become-parents an insight on what the procedure does and how sensitive conclusions are to perturbations, we wrote a small Shiny app as part of the R package trisomy21risk to visualize the results. We hope the tool can be helpful in the individual decision making process associated with first trimester screening. This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. The markdown+Rknitr source code of this blog is available under a GNU General Public License (GPL v3) license from github. Introduction…
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